1. the list contains more home pc's that it does servers,
2. each list owner updates their own,
3. the contents of the lists a moving target.
The blacklists vary considerably in their makup, policy, administation
etc.
Some of the better ones use a spamtrap/honeypot system, so that where
spammers have the spamtrap in their list, the trap is triggered, and
the offending address blacklisted automatically for a set time -
described as an "easy-on / easy-off" list.
Other lists block IP ranges ( a class C or larger ).
Some (not recommended for general use) us highly opinionated criteria,
and may block entire address ranges of ISPs that they consider not to
be acting to resolve spam.
Another very useful trick, is regex filtering (as in Spampal)
My preferred target in spambashing, is to use headers only, so that
the body can be dumped with a "delete from server" action.