Well, knowing what USB devices are plugged into the computer
would help
Some small USB developers, who do not wish to design their
own USB chip, will use a "FTDI chip". FTDI makes a serial
stream device, that allows a small developer to connect
some kind of device that produces a bit stream, to a USB
port. What an "end user" won't understand in a case
like that, is why the USB appliance they bought, has
a "virtual serial port" inside it. It could be that you
need to satisfy this need for an intermediate "virtual
serial port", before the whole function of the USB device
is complete. (I.e. Two drivers needed to make the device
functional, a virtual serial port, plus another level of
driver.)
http://www.ftdichip.com/FTProducts.htm
Using the USB driver disk that came with the USB device
will likely solve this problem, installing whatever is
needed.
Paul