The downside to Sandboxie is the time and effort required to get up to speed, both in terms of the concepts and actually using the software.
It's not a set it and forget it thing. If however, you make the effort to familiarise yourself with Sandboxie, you can be well rewarded.
There is a free and a commercial version of Sandboxie. The free version is missing only a handful of features. One restriction in the free version is that you can only have one sandbox running at a time.
Sandboxie runs under Windows 2000, XP, 2003 and 32bit versions of Vista, no 64bit version.
I installed it. Takes two clicks to open up FF as opposed to one click normally. Does not seem to use a lot of cpu, peaks when opening a new page but drops once opened can not say if this is more or less than normal.
Seems to work as it will not let me do stuff from FF that I normally can. Just wondered how much safer you would be using something like this.