I've been using RegSupreme, (which is an offshoot of JV16) for over 6 months
& wouldn't be without it.
On first installing it, I carefully checked every entry it pulled up & found
they were all legit "destination does not exist" ones, so now just select &
quarantine the lot, leave them for a week or so, then delete the old
quarantined ones.
Until then, I didn't realise that, if, for example, you paste something to
the Desktop, then move it elsewhere - or delete it, a permanent registry
entry is created.
It's not unusual for me to quarantine 50-100 of those types per day. Also,
it's the only totally non-volatile 'cleaner' I've come across to date.