Yes, you can. First, you need to setup Outlook in Corporate Workgroup mode,
not Internet Only mode. Then, under Control Panel/Mail, you can setup
multiple profiles with their own e-mail accounts and Address Books. Last, in
Outlook, under Tools/Options and tab Mail Format, you select to Prompt for
user profile each time you enter Outlook. This way which ever profile you
wish to use you can select. I did this for myself and my wife to keep our
e-mail seperate.