We've tested NTFS on volumes bigger than this with no issues.
The practical issue is backup and chkdsk. Backup, you can
understand the issue there.
If your multi-TB system has millions of files, then CHKDSK time will
be large, though Win2K's chkdsk is 10x faster than NT4, there were
subsequent improvements made in XP and Windows 2003 Server.
(Deep technical reason is that at one point, CHKDSK needs to
verify directory information for files. This requires seeks and reads.
Doing this 10K times isn't much. Doing it millions of times adds up).
If you have oodles of files, I'd recommend having separate volumes
which are joined via volume mount points.
