afaik, all of their designs conform to the right hand, but you would
have to make your own determination if it would "fit"
You can reassign keys, but, since it is a right handed world, doing so
and getting used to it pretty much cripples you when you end up at
another desktop.
As for the "carpal tunnel" issue, isn't not going to be impacted much by
the mouse itself other than minor finger position changes.
if this is an issue you want to address, get a gel wrist rest or one of
the mouse pads which have a wrist rest integrated into the pad itself...
makes a huge difference as does the same type of pad which allows the
wrists to rest supported when typing.
Beverly Howard [MS MVP-Mobile Devices]