Unless the new motherboard is virtually identical to the old one
(same chipset, same IDE controllers, same BIOS version, etc.), you'll
need to perform a repair (a.k.a. in-place upgrade) installation, at
the very least:
This may also require re-activation. If it's been more than 120
days since you last activated that specific Product Key, you'll most
likely be able to activate via the Internet without problem. If it's
been less, you might have to make a 5 minute phone call.