A laptop drive has
1) Better shock spec (factor of 3)
2) Higher start/stop cycle spec (factor of 12)
3) Lower power (factor of 2 to 5)
The laptop drive may not match the performance level
of the desktop drive, but with the sluggish performance
of some backup software, that might not be an issue. For
performance numbers, this is one source (site uses popup
advertising).
http://www.storagereview.com/Testbed4Compare.sr
For enclosures that don't pay attention to proper cooling,
a 2.5" drive is likely to last longer.
With a proper enclosure, there is no reason to fear using
a 3.5" drive. The trick is finding a good enclosure. A
good enclosure is likely to be bigger than you planned on.
Dropping a steel ball bearing on a steel plate, has a
deceleration of around 1000G. (As demonstrated in my
Physics 100 class by our professor.) The 3.5" drive has a
shock spec of 350G (2 milliseconds) when in a non-operating
condition. All it takes, is some deformable material, to
afford sufficient protection (i.e. don't drop metal frame
of drive onto a metal plate).
You can see in this picture, how a retail hard drive is
packaged so it survives the trip to the consumer. The plastic
shell protects the product from a fall from the shelf to the
floor. As long as the plastic packaging is not "cut or bruised",
the product would be safe to buy. You want your enclosure to
have some attention to this as well (avoid solid metal
path from drive to environment, in the hope of staying
below the 350G shock spec for a non-operating drive).
It doesn't take much deformable material, so stay below
350G.
http://www.futureshop.ca/multimedia/products/large/10099566.jpg
Paul