Sometimes, Pop-ups blockers may not be effective in dealing with adware pop-ups. First, clean the system using these tools and carry-on with the same Pop-up blocker which you use now (or try Google Toolbar)
Download all of these utilities and scan the system.
Note: Spyware removers are rules-based and are updated very frequently as and when new malware is discovered. Therefore, update both of these tools before scanning, very important.