We're talking two different things.
This is what I am talking about with that Unblock button which not
applicable in this situation.
http://itsvista.com/2007/01/itsvista-tip-22-stop-security-warning-from-apps-on-vista/
Again, how is the program being started. Is it at system boot and login
that the program is being started and Vista is blocking it or it it
because you are clicking on some desktop icon and it being blocked before
you tell it ok let it run?
It seems that the problem is when you login to the computer and Vista
tries to auto start the program.