Hi Mike,
You can select the cells surrounding your page and set the fill color
to white or whatever, best to go a few extra columns and rows past
the end of your screen. I like to insert a blank column A and row 1
so that I can run the margin color right around my page.
You can also apply borders between your margin and your data.
If you don't want the border to print, set your print area one row
and column smaller.
Another one for visual effect is to hide the row and column
headers by going to Tools>Options>View Tab and uncheck
row and column headers.
If your page fits neatly on one screen you can also zoom in to say
75% then select a cell well off to the bottom right of your page
and go to Window>Freeze Panes. When you zoom back to
100% your page won't move with the scroll bars.
This is all fiddly little smoke and mirrors type stuff but Excel
has never pretended to be a layout program. It's a worksheet
program with a bit of formatting capability thrown in.
HTH
Martin