The short answer is you'll be better off with a notebook drive. You can
also reduce the chances of failure, at the expense of response time, by
powering it down as soon as possible after any use (control panel power
settings I mean, not turning off the computer).
The longer answer depends on what you mean by 'install it in a car'.
'Installed' how?
Vibration dampening is not at all obvious and simply using something
'cushy' can create even worse problems if it sets up resonate vibrations
(which is more likely than you may think). What you need is a material that
actually dampens vibration, not 'springy' (as in rubber). Sorbothane is
such a material. It deforms but does not 'spring' back; it slowly recovers
(a bit like why your car doesn't ride on just springs but also has shock
absorbers. Which, btw, is going to be as important in keeping shock down as
the computer mounting will be since that's your 'first line' shock handler).
A place to start looking into those kinds of problems might be here:
http://www.sorbothane.com/
They have a section on computer isolation concepts.