If your goal is to access a Pervasive DB with ADO.NET you can definitely do
it.
You can access it through either OleDb or Odbc.
http://www.connectionstrings.com/ has an example of using both under the
'Pervasive' section.
You can also install the drivers and then just set up a DSN.
However, from the wording of your question, I think you may be asking how to
get a pervasive DB to appear in visual Studio's server explorer.
I believe that if you aren't using Standard Edition of VS that you can do
it, but I haven't done it personally. To the best of my knowledge, the ODBC
for Pervasive drivers aren't installed on a machine by default but once you
load them you can definitely set up a DSN and you can definitely access a
pervasive db (I've done this personally so I know it's doable) through
ADO.NET. And from the way server explorer works I'd be shocked if you
couldn't add a pervasive DB to it once you have the drivers/dsn installed.