If the folder names look like this $NtUninstallKB817778$ they are the
uninstall files for undoing Window's patches. They should have been placed
in the Windows or WinNT folder (depending on if you installed new or updated
from a NT version of windows). If they are being placed in the root of the
boot drive, there is a configuration error on your system (but I don't off
hand know where it would be located).
If the folder/files are not causing any problem, leave them there. If they
are causing a problem, you may be able to Move them to a different folder
and you would have to move them back if you ever needed them. You can also
archive them with WinZip or other compression software and delete the
original folders.