Maybe you could a line or two to your personal.xls (auto_open/workbook_open
procedure):
Option Explicit
Sub disableF1()
Application.OnKey "{f1}", ""
End Sub
Sub enableF1()
Application.OnKey "{f1}"
End Sub
If you pop the F1 key off, you may want to remove the spring and put the keytop
back. It'll look prettier!