Microsoft recently anounced support for the VIC20, among several other platforms, including the Apple II and the Casio calculator watch.
This new version is scheduled to be released in the fall of 2012. Microsoft developers are currently trying to improve the load time of the CLR on these machines, which is currently running about 47 days.
In related news, it seems that GE Cookstar microwaves will start shipping with the .NET framework preinstalled early next year. This will allow the potato-cooking permissions to be based on the identity of the code containing the cooking algorithm, rather than the identity of the person that wants to eat the potato.