John,
First set keypreview property of your form to "True", then:
Private Sub Form1_keydown(ByVal sender As System.Object, ByVal e As
System.Windows.Forms.KeyEventArgs) Handles MyBase.KeyDown
If e.KeyData = Keys.Control + Keys.A Then
MsgBox("Ctrl+A pressed")
ElseIf e.KeyData = Keys.Control + Keys.B Then
MsgBox("Ctrl+B pressed")
ElseIf e.KeyData = Keys.Control + Keys.C Then
MsgBox("Ctrl+C pressed")
End If