You have to have an Exchange server for Out-of-Office Assistant to be
enabled. You could probably do something similar with an Outlook rule, but
then you have to leave your machine on and checking mail the whole time.
Probably just as well that you don't; any out-of-office autoresponder you
set up is going to automatically reply to everybody who sends you a message,
including the spammers. That's a good way to dramatically increase the
amount of spam you get.