first make sure the program is not a mac program or anything next u might just want to try compatiblity mode. to activate it right click on the .exe and go to complatiblity tab then select what Operating System u would like windows to tell the program it is. then it is done if this does not work try it on another computer.
If u are getting this error Explore.exe is not a valid win32 application do the followin
insert the winxp cd in the cd drive and run this command sfc /scannow from a dos prompt. this will restore any corrupt files if needed. you need to be an administrator to do this. Of course this will remove the updates that u have installed and you wil have to redo the updates