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Some Windows users have been affected by a malware program that imitates Skype software and attempts to steal sensitive information.
65404-SkypeDefenderSetup.exe is classified as an Infostealer, that is, a Trojan horse program that attempts to steal sensitive information such as login credentials.
http://share.skype.com/sites/security/2007/10/skype_defender_malware_alert.html
Update your AV program, however, manual removal it is enough to delete the 65404-SkypeDefenderSetup.exe file.
65404-SkypeDefenderSetup.exe is classified as an Infostealer, that is, a Trojan horse program that attempts to steal sensitive information such as login credentials.
http://share.skype.com/sites/security/2007/10/skype_defender_malware_alert.html
Update your AV program, however, manual removal it is enough to delete the 65404-SkypeDefenderSetup.exe file.